Research Projects

Clinical Trials

 
Currently Enrolling Clinical Trials:

Study Drug (Sponsor)

Condition

Key Inclusion Criteria

Telitacecept (RemeGen)

IgA Nephropathy

  • Biopsy-proven IgA Nephropathy
  • Adults 18-70 years of age
  • Proteinuria at least 0.75g/day
  • eGFR > 30

IGNAZ: Felzartamab (MorphoSys)

IgA Nephropathy

  • Biopsy-proven IgA Nephropathy
  • Adults 18-80 years of age
  • Proteinuria at least 1g/day

ALIGN: Atrasentan (Chinook)

IgA Nephropathy

  • Biopsy-proven IgA Nephropathy
  • Adults 18 years or older
  • Proteinuria at least 1g/day
  • eGFR > 30

Please contact research coordinator Divya Seth [email protected] if you or your patient is interested in participating in any of the above studies. 

 

UPCOMING CLINICAL TRIALS:

Study Drug (Sponsor)

Condition

Key Inclusion Criteria

REBOOT: Belimumab with Rituximab (ITN)

Primary Membranous Nephropathy

  • Biopsy confirmation within 5 years
  • Serum anti-PLA2R positive
  • Proteinuria at least 4g/day on max tolerated RAS blockade
  • eGFR > 30

VB119 (ValenzaBio)

Primary Membranous Nephropathy

  • Biopsy confirmation within 10 years
  • Adults 18 years or older
  • Proteinuria at least 3.5g/day
  • eGFR at least 45

VB119 (ValenzaBio)

Focal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD)

  • Biopsy confirmation within 10 years
  • History of steroid-sensitive MCD or FSGS
  • Adults 18 years or older
  • Proteinuria > 2g/day during/after steroid taper
  • eGFR at least 60

VIS649 (Otsuka)

IgA Nephropathy

  • Biopsy-proven IgA Nephropathy
  • Adults 18 years or older
  • Proteinuria at least 0.75g/day
  • eGFR >45

Please contact research coordinator Divya Seth [email protected] if you or your patient is interested in participating in any of the above studies.

 

Cohorts & Collaborations 

UCSF Autoimmunoprofiler:  A translational platform to enhance treatment efficacy, develop precision medicines and understand the immunological basis for disease.  We will be prospectively collecting kidney tissue samples from patients with autoimmune diseases such as lupus, to help with better understanding of underlying mechanisms of autoimmune diseases, identification of the relationship between tissue and peripheral compartment, and the identification of novel pathways and targets for future drug discovery and development.

CKDopps: The Chronic Kidney Disease Outcomes and Practice Patterns Study.  We are a recruitment and collaborating site for this multinational CKD cohort study

GlomCon: The Glomerular Disease Glomerular Disease Study & Trial Consortium.  We are involved in building a clinical data registry and in the educational mission of GlomCon.

ICPi-AKI Consortium based at the Brigham & Women's Hospital/Harvard Medical School.  We are actively collaborating with this multinational consortium of investigators studying the renal effects of immune checkpoint inhibitors among patients with cancer. 

International Kidney Disorder Registry (K-REG) based at the University of Pennsylvania Glomerular Disease Center.  We are a contributing site for this international registry with a focus on rare kidney disorders. 

 

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